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Institutional Animal Care and Use Committee

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About

The Institutional Animal Care and Use Committee (IACUC) is dedicated to the task of facilitating and assisting faculty in the conduct of research, teaching and other activities involving the use of laboratory animals.  The committee consists of a minimum of 5 voting members from the faculty, administration, and community, and must include a scientist, a non-scientist, and a person unaffiliated with the university and its animal care program. The IACUC is responsible for assuring that all animal use complies with the   Animal Welfare Act, Public Health Service (PHS)   Policy on Humane Care and Use of Laboratory Animals, the   Guide for the Care and Use of Laboratory Animals and all other applicable regulations, policies and procedures. Any use of animals at GRU without IACUC approval is a violation of GRU policy and federal law.

Functions

  • Semi-annual evaluation of the animal care program
  • Semi-annual inspection of facilities
  • Report to Institutional Official and OLAW
  • Advise on the animal care program, facilities and
    personnel training
  • Review animal use protocols
  • Review animal welfare concerns
  • Empowered to suspend animal activity in event of non-compliance

Animal Welfare Responsibility

Responsibility for animal welfare at GRU ultimately lies with the University President.  These responsibilities are formally delegated as follows:

  1. The President appoints an Institutional Offiicial (IO).
  2. The IO appoints the members and chair of the Animal Care and use Committee (IACUC), and has authority to allocate organizational resources needed to maintain a smoothly functioning animal care and use program based on the recommendations and advice received from the IACUC, the veterinarian, and the IACUC staff.
  3. The IACUC reports directly to the IO, through the IACUC Chair, and performs its duties without undue interference.
  4. The veterinarian, also a member of IACUC, reports directly to the IO in connection with his or her responsibility for implementing the animal care and use program.
  5. The IACUC office consists of staff to provide administrative support to the IACUC and the IO.
  6. Investigators submit animal use proposals to the IACUC for review and approve or disapprove, in accordance with the PHS Policy, the Guide, and the Animal Welfare Regulations (AWR).

Committee Conflict of Interest Policy

No member may participate in the IACUC review or approval of a protocol in which the member has a conflicting interest or is personally involved in the project. A member with a conflict of interest may provide information requested by the IACUC, but may not participate in the discussion or vote.  The conflicted member will be excused during the discussion and vote and their attendance will not be counted towards a quorum. If a member of the IACUC is excused because of conflict of interest, and a quorum is no longer present, a decision on the protocol will be deferred until the next meeting. The Chair or an IACUC committee member may request that a member be excused from committee deliberations on a specific protocol because of possible or perceived conflict of interest.

Compliance Enforcement

The United States Department of Agriculture (USDA) enforces GRU compliance with the Animal Welfare Act by conducting at least one unannounced inspection tours each year. IACUC records and the animal use facilities are examined. The Office of Laboratory Animal Welfare (OLAW) of the National Institutes of Health (NIH) enforces the Public Health Service (PHS)   Policy on Humane Care and Use of Laboratory Animals. OLAW makes announced inspections of animal care and use procedures at GRU. Either agency can request suspension of federal support for GRU's research efforts if the institution is found to be in violation of regulations.

The IACUC has been given oversight responsibility to enforce USDA regulations and the GRU Assurance of Compliance with Public Health Service Policy on Humane Care and Use of Laboratory Animals by federal regulatory law. The Animal Use Protocol (AUP) provides the basis for compliance and IACUC approval provides the assurance. Thus, investigators must closely adhere to the AUP for every aspect of animal care and use. Inappropriate animal care or treatment (including deviations from those approved in the AUP) will be investigated by the IACUC. An AUP can be suspended by a majority vote by the IACUC, an action, which by law cannot be reversed by an institutional official. OLAW is notified of such an occurrence whether or not the project is federally funded. The IACUC will notify the investigator of the corrective actions needed to reinstate the AUP.

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